The paper describes the development of a mul-tidisciplinary design optimization framework for con-ceptual design of truss-braced wing configurations. This unconventional configuration requires specialized analysis tools supported by a modular and flexible framework to accommodate different configurations. While the previous framework developed at Virginia Tech was a monolithic Fortran-77 code, the need for more flexibility for com-plex truss-braced wing configurations was addressed by the development of this new framework, which is based on Phoenix Integration ModelCenterTM environment. The framework uses updated structural and aerodynamic de-sign modules that enable a more general geometry defini-tion. The new framework, thus, provides a foundation for future design concepts, especially multi-member truss-braced wing configurations. The fuel saving potential of these truss-braced wing configurations is presented by com-paring different truss designs with gradually increased level of complexity.