As filed with the Securities and Exchange Commission on September 11, 2018

Registration No. 333-226822

SECURITIES AND EXCHANGE COMMISSION

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WASHINGTON, DC 20549

AMENDMENT NO. 5

TO

FORM F-1

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

NIO Inc.

(Exact name of Registrant as specified in its charter)

Not Applicable

(Translation of Registrant’s name into English)

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